@patent{NAN2019,
title = {Method for enhancing mass spectrometric detection repetitiveness by eliminating dessert effect },
author = {LYU NAN and LI NING and DOU SHUZHEN and ZHU QUNYAN and WANG ZHONGSHUN and TENG FEI
},
url = {https://worldwide.espacenet.com/publicationDetails/biblio?CC=CN&NR=106483191B&KC=B&FT=D},
year = {2019},
date = {2019-03-08},
number = {CN106483191B},
abstract = {The invention relates to a method for enhancing mass spectrometric detection repetitiveness by eliminating dessert effect, belonging to the technical field of detection. Under the weak hydrophobic actions, since polymethyl methacrylate can adsorb some hydrophobic proteins and polypeptides, a polymethyl-methacrylate-site-modified hydrophobic silicon nanopillar array is utilized to provide uniform absorption sites and is inverted in a stirred detected molecule solution; when the array is taken out, no liquid film can be attached to the surface under the hydrophobic actions of the array so as to prevent the coffee-ring effect, and thus, the molecules are uniformly adsorbed to every nanopillar; and finally, the substrate is dropwisely added, and since the volatilization speed of the solution composed of acetonitrile and trifluoroacetic acid which are volatile solvents is greater than the molecule migration speed to both ends, the substrate can not have the coffee-ring effect even after being dried. In general, the method provided by the invention ensures the uniform distribution of the molecules and substrate, thereby greatly enhancing the detection repetitiveness of the detected molecules.
},
keywords = {Spectrometer},
pubstate = {published},
tppubtype = {patent}
}
The invention relates to a method for enhancing mass spectrometric detection repetitiveness by eliminating dessert effect, belonging to the technical field of detection. Under the weak hydrophobic actions, since polymethyl methacrylate can adsorb some hydrophobic proteins and polypeptides, a polymethyl-methacrylate-site-modified hydrophobic silicon nanopillar array is utilized to provide uniform absorption sites and is inverted in a stirred detected molecule solution; when the array is taken out, no liquid film can be attached to the surface under the hydrophobic actions of the array so as to prevent the coffee-ring effect, and thus, the molecules are uniformly adsorbed to every nanopillar; and finally, the substrate is dropwisely added, and since the volatilization speed of the solution composed of acetonitrile and trifluoroacetic acid which are volatile solvents is greater than the molecule migration speed to both ends, the substrate can not have the coffee-ring effect even after being dried. In general, the method provided by the invention ensures the uniform distribution of the molecules and substrate, thereby greatly enhancing the detection repetitiveness of the detected molecules.
App. No. 62/799,324 (Pending), 2019, (50 nm thin metasurface technology for controlling vectorial light beams with 99% experimental efficiency across all the visible and made from inexpensive material with CMOS compatible large scale manufacturing. (App. No. 62/799,324)).
@misc{fratax2019,
title = {Flat optics polarizing beam splitter},
author = {Andrea Fratalocchi and Arturo Burguete Lopez and Maxsim Makarenko and Fedor Getman},
year = {2019},
date = {2019-01-01},
crossref = {U.S. Application No. 62/799,324},
howpublished = {App. No. 62/799,324 (Pending)},
note = {50 nm thin metasurface technology for controlling vectorial light beams with 99% experimental efficiency across all the visible and made from inexpensive material with CMOS compatible large scale manufacturing. (App. No. 62/799,324)},
keywords = {AI photonics},
pubstate = {published},
tppubtype = {misc}
}
Fratalocchi, Andrea; cruz, Alouizio M; Mazzone, Valerio; Falco, Andrea Di
Optical encryption terminal, cryptography key distribution system and method of generating cryptography keys in a cryptography key distribution system Patent
2018, (In an aspect, the present invention provides an optical encryption terminal (110A) for generating and distributing a cryptographic key signal in a cryptography key distribution system (100) having at least two optical encryption terminals (110A, 110B). The optical encryption terminal (110A) comprises an electronic processing unit (116A) and the optical encryption terminal (110A) is configured to selectively receive optical input signals (OIS-A) generated by a source (120A) of electromagnetic radiation and optical input signals (OOS-B) generated by a further optical encryption terminal (110B), and to selectively output first optical output signals (OOS-AB) to a detection element (130A) and second optical output signals (OOS-A) to the further optical encryption terminal (110B), wherein the first optical output signals (OOS-AB) are based on the optical input signals (OOS-B) generated by the further optical encryption terminal (110B) and transformed in accordance with an optical encryption pattern (114A) provided at the optical encryption terminal (110A). Furthermore, the optical encryption terminal (110A) is configured to determine, using the electronic processing unit (116A), a cryptographic key signal (keyA) on the basis of at least one radiometric and/or photometric quantity associated with the optical output signals (OOS-AB) detected by the detection element (130A).).
@patent{fratax2018,
title = {Optical encryption terminal, cryptography key distribution system and method of generating cryptography keys in a cryptography key distribution system},
author = {Andrea Fratalocchi and Alouizio M cruz and Valerio Mazzone and Andrea Di Falco},
year = {2018},
date = {2018-07-01},
crossref = {USPTO16132017},
howpublished = {Pending},
note = {In an aspect, the present invention provides an optical encryption terminal (110A) for generating and distributing a cryptographic key signal in a cryptography key distribution system (100) having at least two optical encryption terminals (110A, 110B). The optical encryption terminal (110A) comprises an electronic processing unit (116A) and the optical encryption terminal (110A) is configured to selectively receive optical input signals (OIS-A) generated by a source (120A) of electromagnetic radiation and optical input signals (OOS-B) generated by a further optical encryption terminal (110B), and to selectively output first optical output signals (OOS-AB) to a detection element (130A) and second optical output signals (OOS-A) to the further optical encryption terminal (110B), wherein the first optical output signals (OOS-AB) are based on the optical input signals (OOS-B) generated by the further optical encryption terminal (110B) and transformed in accordance with an optical encryption pattern (114A) provided at the optical encryption terminal (110A). Furthermore, the optical encryption terminal (110A) is configured to determine, using the electronic processing unit (116A), a cryptographic key signal (keyA) on the basis of at least one radiometric and/or photometric quantity associated with the optical output signals (OOS-AB) detected by the detection element (130A).},
keywords = {Perfect Secrecy},
pubstate = {published},
tppubtype = {patent}
}
Fratalocchi, Andrea; Fabrizio, Enzo Di; Gongora, Juan Sebastian Totero; Coluccio, Maria Laura; Candeloro, Patrizio; Cuda, Gianni
Analytic device including nanostructures Patent
2017, (A device for detecting an analyte in a sample comprising: an array including a plurality of pixels, each pixel including a nanochain comprising: a first nanostructure, a second nanostructure, and a third nanostructure, wherein size of the first nanostructure is larger than that of the second nanostructure, and size of the second nanostructure is larger than that of the third nanostructure, and wherein the first nanostructure, the second nanostructure, and the third nanostructure are positioned on a substrate such that when the nanochain is excited by an energy, an optical field between the second nanostructure and the third nanostructure is stronger than an optical field between the first nanostructure and the second nanostructure, wherein the array is configured to receive a sample; and a detector arranged to collect spectral data from a plurality of pixels of the array).
@patent{patent2017,
title = {Analytic device including nanostructures},
author = {Andrea Fratalocchi and Enzo Di Fabrizio and Juan Sebastian Totero Gongora and Maria Laura Coluccio and Patrizio Candeloro and Gianni Cuda},
year = {2017},
date = {2017-11-01},
crossref = {https://patents.justia.com/inventor/andrea-fratalocchi},
howpublished = {Granted},
note = {A device for detecting an analyte in a sample comprising: an array including a plurality of pixels, each pixel including a nanochain comprising: a first nanostructure, a second nanostructure, and a third nanostructure, wherein size of the first nanostructure is larger than that of the second nanostructure, and size of the second nanostructure is larger than that of the third nanostructure, and wherein the first nanostructure, the second nanostructure, and the third nanostructure are positioned on a substrate such that when the nanochain is excited by an energy, an optical field between the second nanostructure and the third nanostructure is stronger than an optical field between the first nanostructure and the second nanostructure, wherein the array is configured to receive a sample; and a detector arranged to collect spectral data from a plurality of pixels of the array},
keywords = {},
pubstate = {published},
tppubtype = {patent}
}
@patent{NAN2017,
title = {Method for improving desorption ionization efficiency by enriching analyte to metal nanocone array tip },
author = {LYU NAN and LI NING and DOU SHUZHEN and TENG FEI and DU JUAN},
url = {https://worldwide.espacenet.com/publicationDetails/biblio?CC=CN&NR=106885839A&KC=A&FT=D},
year = {2017},
date = {2017-06-23},
number = {CN106885839A},
abstract = {The invention discloses a surface assistant laser desorption ionization mass spectrometry analysis method for improving desorption ionization efficiency of analyte by enriching the analyte to a metal nanocone array tip, and belongs to the technical field of detection. A metal membrane is applied to the surface of a silicon nanocone array in an evaporation manner, then surface plasma element conduction is carried out, photon energy is accumulated in tip positions, and thus a photon library is formed. As the surface is modified with fluoro-substitution alkyl sulfhydryl, a substrate has a large contact angle and a small rolling angle, then the friction of water droplets on the substrate is very small, analyte molecules of a solution are preferentially concentrated at the tips, and the utilization rate of laser energy can be further increased. Therefore, when the silicon nanocone array covered by the metal membrane modified with the fluoro-substitution alkyl sulfhydryl is used as substrate detection analyte molecules, the laser energy can be sufficiently absorbed and effectively utilized, furthermore the desorption ionization efficiency of the analyte molecules can be improved, and the method is applicable to various types of molecules.
The invention discloses a surface assistant laser desorption ionization mass spectrometry analysis method for improving desorption ionization efficiency of analyte by enriching the analyte to a metal nanocone array tip, and belongs to the technical field of detection. A metal membrane is applied to the surface of a silicon nanocone array in an evaporation manner, then surface plasma element conduction is carried out, photon energy is accumulated in tip positions, and thus a photon library is formed. As the surface is modified with fluoro-substitution alkyl sulfhydryl, a substrate has a large contact angle and a small rolling angle, then the friction of water droplets on the substrate is very small, analyte molecules of a solution are preferentially concentrated at the tips, and the utilization rate of laser energy can be further increased. Therefore, when the silicon nanocone array covered by the metal membrane modified with the fluoro-substitution alkyl sulfhydryl is used as substrate detection analyte molecules, the laser energy can be sufficiently absorbed and effectively utilized, furthermore the desorption ionization efficiency of the analyte molecules can be improved, and the method is applicable to various types of molecules.
@patent{LYU2016,
title = {Method for preparing thin film ordered microstructure based on a reaction ion beam etching technology},
author = {NAN LYU and NING LI and FEI TENG and LEI FENG and FEIFEI WU},
url = {https://worldwide.espacenet.com/publicationDetails/biblio?CC=CN&NR=104555910B&KC=B&FT=D},
year = {2016},
date = {2016-01-01},
number = {CN104555910B},
publisher = {China},
abstract = {The invention provides a method for preparing ordered thin film patterns based on a reaction ion etching polymer and belongs to the technical field of ordered microstructures. Specifically, reaction ion etching is conducted on a substrate and single-layer polymeric microspheres on the surface of the substrate, accordingly the ordered thin film patterns are formed on the surface of the substrate and can be regulated and controlled by changing reaction ion etching parameters. Furthermore, electroless deposition is conducted on the surface of the substrate, metal nano particles can be selectively absorbed in the area provided with no a thin film or a non-compact thin film, and further an ordered array of the metal nano particles is formed. The ordered array of the metal nano particles has certain application value on the aspects of Raman detection and plasma regulation and control.; In addition, due to the fact that the surface of the generated thin film is provided with functional groups, the method can be applied to selective self assembly, preferential absorption of enzyme and protein and also has good application prospect on the aspects of biological monitoring and sensing.},
keywords = {},
pubstate = {published},
tppubtype = {patent}
}
The invention provides a method for preparing ordered thin film patterns based on a reaction ion etching polymer and belongs to the technical field of ordered microstructures. Specifically, reaction ion etching is conducted on a substrate and single-layer polymeric microspheres on the surface of the substrate, accordingly the ordered thin film patterns are formed on the surface of the substrate and can be regulated and controlled by changing reaction ion etching parameters. Furthermore, electroless deposition is conducted on the surface of the substrate, metal nano particles can be selectively absorbed in the area provided with no a thin film or a non-compact thin film, and further an ordered array of the metal nano particles is formed. The ordered array of the metal nano particles has certain application value on the aspects of Raman detection and plasma regulation and control.; In addition, due to the fact that the surface of the generated thin film is provided with functional groups, the method can be applied to selective self assembly, preferential absorption of enzyme and protein and also has good application prospect on the aspects of biological monitoring and sensing.
@patent{Cuda2014,
title = {Analytic device including nanostructures},
author = {Enzo Di Fabrizio Cuda and Andrea Fratalocchi and Juan Sebastian Totero Gongora and Maria Laura Coluccio and Patrizio Candeloro and Gianni Cuda},
url = {https://patents.google.com/patent/US9835561B2/en},
year = {2014},
date = {2014-12-01},
number = {US9835561B2},
abstract = {A device for detecting an analyte in a sample comprising: an array including a plurality of pixels, each pixel including a nanochain comprising: a first nanostructure, a second nanostructure, and a third nanostructure, wherein size of the first nanostructure is larger than that of the second nanostructure, and size of the second nanostructure is larger than that of the third nanostructure, and wherein the first nanostructure, the second nanostructure, and the third nanostructure are positioned on a substrate such that when the nanochain is excited by an energy, an optical field between the second nanostructure and the third nanostructure is stronger than an optical field between the first nanostructure and the second nanostructure, wherein the array is configured to receive a sample; and a detector arranged to collect spectral data from a plurality of pixels of the array.},
keywords = {},
pubstate = {published},
tppubtype = {patent}
}
A device for detecting an analyte in a sample comprising: an array including a plurality of pixels, each pixel including a nanochain comprising: a first nanostructure, a second nanostructure, and a third nanostructure, wherein size of the first nanostructure is larger than that of the second nanostructure, and size of the second nanostructure is larger than that of the third nanostructure, and wherein the first nanostructure, the second nanostructure, and the third nanostructure are positioned on a substrate such that when the nanochain is excited by an energy, an optical field between the second nanostructure and the third nanostructure is stronger than an optical field between the first nanostructure and the second nanostructure, wherein the array is configured to receive a sample; and a detector arranged to collect spectral data from a plurality of pixels of the array.
