@patent{NAN2019,

title = {Method for enhancing mass spectrometric detection repetitiveness by eliminating dessert effect  },

author = {LYU NAN and LI NING and DOU SHUZHEN and ZHU QUNYAN and WANG ZHONGSHUN and TENG FEI





},

url = {https://worldwide.espacenet.com/publicationDetails/biblio?CC=CN&NR=106483191B&KC=B&FT=D},

year  = {2019},

date = {2019-03-08},

number = {CN106483191B},

abstract = {The invention relates to a method for enhancing mass spectrometric detection repetitiveness by eliminating dessert effect, belonging to the technical field of detection. Under the weak hydrophobic actions, since polymethyl methacrylate can adsorb some hydrophobic proteins and polypeptides, a polymethyl-methacrylate-site-modified hydrophobic silicon nanopillar array is utilized to provide uniform absorption sites and is inverted in a stirred detected molecule solution; when the array is taken out, no liquid film can be attached to the surface under the hydrophobic actions of the array so as to prevent the coffee-ring effect, and thus, the molecules are uniformly adsorbed to every nanopillar; and finally, the substrate is dropwisely added, and since the volatilization speed of the solution composed of acetonitrile and trifluoroacetic acid which are volatile solvents is greater than the molecule migration speed to both ends, the substrate can not have the coffee-ring effect even after being dried. In general, the method provided by the invention ensures the uniform distribution of the molecules and substrate, thereby greatly enhancing the detection repetitiveness of the detected molecules.

},

keywords = {Spectrometer},

pubstate = {published},

tppubtype = {patent}

}